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ADRB1 抗体 (Internal Region)

Verified ADRB1 适用: 人 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN185584
发货至: 中国
  • 抗原 See all ADRB1 抗体
    ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))
    抗原表位
    • 16
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 36
    • 28
    • 27
    • 6
    • 6
    • 2
    • 1
    • 1
    宿主
    • 38
    山羊
    克隆类型
    • 38
    多克隆
    标记
    • 13
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ADRB1 antibody is un-conjugated
    应用范围
    • 32
    • 19
    • 13
    • 13
    • 10
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    原理
    ADRB1
    序列
    ESDEARRCYN DPK
    交叉反应
    犬, 人, 小鼠, 大鼠
    纯化方法
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
    质量等级
    Verified
    免疫原
    Peptide with sequence ESDEARRCYNDPK, from the internal region of the protein sequence according to NP_000675.1.
    亚型
    IgG
  • 应用备注

    Immunohistochemistry: Paraffin embedded Human Heart. Recommended concentration: 6 μg/mL.

    Western Blot: This antibody is not recommended for use in Western blotting.

    Peptide ELISA: antibody detection limit dilution 1:2000.

    说明

    Immunofluorescence: Strong expression of the protein seen in the plama membrane and cytoplasm of HeLa cells. Recommended concentration: 10μg/ml.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Minimize freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Aliquot and store at -20°C, with minimal freeze/thawing. A working aliquot may be refrigerated at 4°C for a few weeks and still remain viable.
  • Wenzel, Schulze-Rothe, Müller, Wallukat, Haberland: "Difference between beta1-adrenoceptor autoantibodies of human and animal origin-Limitations detecting beta1-adrenoceptor autoantibodies using peptide based ELISA technology." in: PLoS ONE, Vol. 13, Issue 2, pp. e0192615, (2018) (PubMed).

    Wallukat, Prüss, Müller, Schimke: "Functional autoantibodies in patients with different forms of dementia." in: PLoS ONE, Vol. 13, Issue 3, pp. e0192778, (2018) (PubMed).

    Wenzel, Schulze-Rothe, Haberland, Müller, Wallukat, Davideit: "Performance and in-house validation of a bioassay for the determination of beta1-autoantibodies found in patients with cardiomyopathy." in: Heliyon, Vol. 3, Issue 7, pp. e00362, (2017) (PubMed).

    Wallukat, Haberland, Berg, Schulz, Freyse, Dahmen, Kage, Dandel, Vetter, Salzsieder, Kreutz, Schimke: "The first aptamer-apheresis column specifically for clearing blood of ?1-receptor autoantibodies." in: Circulation journal : official journal of the Japanese Circulation Society, Vol. 76, Issue 10, pp. 2449-55, (2012) (PubMed).

    Haberland, Wallukat, Dahmen, Kage, Schimke: "Aptamer neutralization of beta1-adrenoceptor autoantibodies isolated from patients with cardiomyopathies." in: Circulation research, Vol. 109, Issue 9, pp. 986-92, (2011) (PubMed).

    Wallukat, Muñoz Saravia, Haberland, Bartel, Araujo, Valda, Duchen, Diaz Ramirez, Borges, Schimke: "Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients." in: Journal of the American College of Cardiology, Vol. 55, Issue 5, pp. 463-8, (2010) (PubMed).

  • 抗原
    ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))
    别名
    ADRB1 (ADRB1 产品)
    别名
    ADRB1R antibody, B1AR antibody, BETA1AR antibody, RHR antibody, RATB1AR antibody, X-Beta1AR antibody, BAR1 antibody, zgc:194728 antibody, zgc:194731 antibody, ADRB1 antibody, Adrb-1 antibody, beta-AR antibody, adrenoceptor beta 1 antibody, adrenoceptor beta 1 L homeolog antibody, adrenergic, beta-1-, receptor antibody, adrenergic receptor, beta 1 antibody, ADRB1 antibody, Adrb1 antibody, adrb1.L antibody, adrb1 antibody
    背景
    ADRB1, adrenergic, beta-1-, receptor, ADRB1R, B1AR, BETA1AR, RHR, beta-1-adrenergic receptor
    分子量
    51.2kDa
    基因ID
    153
    NCBI登录号
    NP_000675
    途径
    cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Brown Fat Cell Differentiation
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