ADAM10 抗体 (Extracellular, N-Term)
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Quick Overview for ADAM10 抗体 (Extracellular, N-Term) (ABIN7042880)
抗原
See all ADAM10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 400-414, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to ADAM10 (extracellular)
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human - identical
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产品特性
- Anti-ADAM10 (extracellular) Antibody (ABIN7042880, ABIN7044734 and ABIN7044735) is a highly specific antibody directed against an extracellular epitope of mouse ADAM10. The antibody can be used in western blot, Indirect flow cytometry and immunohistochemistry. It has been designed to recognize ADAM10 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CTPGESKNLGQKENG, corresponding to amino acid residues 400 - 414 of mouse ADAM10
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亚型
- IgG
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anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 420-641) antibody
ADAM10 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6C3C7 unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 214-504) antibodyADAM10 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 501-600) antibodyADAM10 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 732-748) antibodyADAM10 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 适用: 人 WB, FACS, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal 11G2 unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibody (PE)ADAM10 适用: 人 FACS 宿主: 小鼠 Monoclonal 11G2 PE
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3920 unconjugated Recombinant Antibody
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 218-445) antibodyADAM10 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:500
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234615)
Blocking Peptide: (ABIN7234615)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))
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别名
- ADAM10
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背景
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Synonyms: Disintegrin And Metalloproteinase Domain-Containing Protein 10, ADAM Metallopeptidase Domain 10, CD156c
Description: Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10, is a membrane-anchored protease that belongs to the ADAM protease family. ADAMs are type I transmembrane proteins with a large extracellular domain and a shorter cytosolic part, they contain a metalloprotease domain, a disintegrin domain, a cystein-rich domain, an EGF-like domain, a transmembrane domain and a cytoplasmic tail2. 37 murine and 22 human ADAMs are known and only some of them contain the catalytically relevant domain (HEXGHXXGXXHD) and are therefore able to cleave the extracellular domains of several membrane-bound proteins in a process known as 'ectodomain shedding'1. This process represents a unique and irreversible posttranslational event regulating the function and half-life of many intracellular and extracellular proteins and hence the ADAM family protein's activity is essential for regulation of various cellular functions2. ADAM10 has many substrates, among which are cellular adhesion molecules such as cadherin, receptors and ligands3. it is also capable of anti-amyloidogenic proteolysis of the amyloid precursor protein, this is why ADAM10 mutations were shown to be correlated with Alzheimer's disease2. In addition, it was shown to involved in various human diseases and disorders such as Huntington's disease, psoriasis, lupus, and multiple types of cancer. The central role of ADAM10 in various cell processes and diseases reveals the potency of ADAM10-targeting drug development as a future therapeutic option2.
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基因ID
- 11487
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NCBI登录号
- NM_001110
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UniProt
- O35598
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途径
- Notch Signaling, EGFR Signaling Pathway
抗原
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