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ube3a 抗体

This anti-ube3a antibody is a 兔 多克隆 antibody detecting ube3a in WB 和 IHC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7259701
发货至: 中国

Quick Overview for ube3a 抗体 (ABIN7259701)

抗原

See all ube3a 抗体
ube3a (Ubiquitin Protein Ligase E3A (ube3a))

适用

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人, 小鼠, 大鼠

宿主

  • 51
  • 6

克隆类型

  • 49
  • 8
多克隆

标记

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This ube3a antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 产品特性

    Polyclonal Antibody

    纯化方法

    Affinity purification

    免疫原

    Recombinant fusion protein of human UBE3A (NP_570853.1).

    亚型

    IgG
  • 应用备注

    WB 1:500-1:2000 IHC 1:50-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    ube3a (Ubiquitin Protein Ligase E3A (ube3a))

    别名

    UBE3A

    背景

    This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

    分子量

    Observed_MW: 110 kDa

    Calculated_MW: 97 kDa/100 kDa

    基因ID

    7337

    UniProt

    Q05086

    途径

    Intracellular Steroid Hormone Receptor Signaling Pathway
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