F12 抗体
Quick Overview for F12 抗体 (ABIN7259454)
抗原
See all F12 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of human F12 (NP_000496.2).
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亚型
- IgG
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anti-Coagulation Factor XII (F12) (AA 400-615) antibody
F12 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 352-587) antibodyF12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 191-300) antibodyF12 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3A3 unconjugated
anti-Coagulation Factor XII (F12) antibodyF12 适用: 人 ELISA, IHC, IP, IHC (p), IEP 宿主: 山羊 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (C-Term) antibodyF12 适用: 人, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (Cleaved-Arg372) antibodyF12 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (AA 486-600) antibodyF12 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (N-Term) antibodyF12 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor XII (F12) (Heavy Chain), (N-Term) antibodyF12 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- F12 (Coagulation Factor XII (F12))
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别名
- F12
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背景
- This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
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分子量
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Observed_MW: 71 kDa
Calculated_MW: 67 kDa
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基因ID
- 2161
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UniProt
- P00748
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途径
- Complement System
抗原
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