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CASR 抗体

This anti-CASR antibody is a 兔 多克隆 antibody detecting CASR in ELISA 和 IHC. Suitable for 人.
产品编号 ABIN7246118
发货至: 中国

Quick Overview for CASR 抗体 (ABIN7246118)

抗原

See all CASR 抗体
CASR (Calcium-Sensing Receptor (CASR))

适用

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宿主

  • 93
  • 11

克隆类型

  • 95
  • 9
多克隆

标记

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  • 1
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This CASR antibody is un-conjugated

应用范围

  • 80
  • 35
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ELISA, Immunohistochemistry (IHC)
  • 产品特性

    Polyclonal Antibody

    纯化方法

    Antigen affinity purification

    免疫原

    Fusion protein of human CASR

    亚型

    IgG
  • 应用备注

    IHC 1:50-1:300, ELISA 1:5000-1:10000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 mg/mL

    缓冲液

    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    CASR (Calcium-Sensing Receptor (CASR))

    别名

    CASR

    背景

    CASR (Calcium Sensing Receptor) is a Protein Coding gene. Diseases associated with CASR include Hypocalcemia, Autosomal Dominant and Hyperparathyroidism, Neonatal. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protein kinase binding. An important paralog of this gene is GPRC6A.The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

    UniProt

    P41180

    途径

    Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
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