HLA-DOB 抗体
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北京 101111
Quick Overview for HLA-DOB 抗体 (ABIN7245230)
抗原
See all HLA-DOB 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Antigen affinity purification
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免疫原
- Synthetic peptide of human HLA-DOB
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亚型
- IgG
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anti-Major Histocompatibility Complex, Class II, DO beta (HLA-DOB) (AA 1-273) antibody
HLA-DOB 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DO beta (HLA-DOB) (AA 1-273) antibodyHLA-DOB 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DO beta (HLA-DOB) (N-Term) antibodyHLA-DOB 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DO beta (HLA-DOB) (AA 27-116) antibodyHLA-DOB 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DO beta (HLA-DOB) antibodyHLA-DOB 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.2 mg/mL
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缓冲液
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- HLA-DOB (Major Histocompatibility Complex, Class II, DO beta (HLA-DOB))
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别名
- HLA-DOB
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背景
- HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB1.
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分子量
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Observed_MW: Refer to figures
Calculated_MW: 31 kDa
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UniProt
- P13765
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途径
- Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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