UBD 抗体 (AA 80-130)
Our Local Distributor
北京 101111
Quick Overview for UBD 抗体 (AA 80-130) (ABIN6992138)
抗原
See all UBD 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 80-130
-
特异性
- UBD antibody is human specific.
-
纯化方法
- UBD antibody is affinity chromatography purified via peptide column.
-
免疫原
- UBD antibody was raised against a 16 amino acid peptide near the center of human UBD. The immunogen is located within amino acids 80 - 130 of UBD.
-
亚型
- IgG
-
-
-
-
应用备注
-
UBD antibody can be used for detection of UBD by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- UBD antibody is supplied in PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,4 °C
-
储存方法
- UBD antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
-
-
- UBD (Ubiquitin D (UBD))
-
别名
- UBD
-
背景
- UBD, also designated ubiquitin D or diubiquitin, plays a role in antigen presentation, cytokine response and apoptosis. It is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin (1,2). UBD is inducible by interferon gamma and TNF-alpha and regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha (3). It may also regulate cell growth during dendritic cell or B cell activation and development (4,5).
-
分子量
-
Predicted: 18 kDa
Observed: 17 kDa -
基因ID
- 10537
-
NCBI登录号
- NP_006389
-
UniProt
- O15205
-
途径
- Ubiquitin Proteasome Pathway
抗原
-