EZH2 抗体 (N-Term)
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北京 101111
Quick Overview for EZH2 抗体 (N-Term) (ABIN6991517)
抗原
See all EZH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 190-240, N-Term
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特异性
- Multiple isoforms of EZH2 are known to exist. EZH2 antibody is predicted to not cross-react with EZH1.
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纯化方法
- EZH2 Antibody is affinity chromatography purified via peptide column.
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免疫原
- EZH2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human EZH2. The immunogen is located within amino acids 190 - 240 of EZH2.
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亚型
- IgG
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应用备注
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EZH2 antibody can be used for detection of EZH2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- EZH2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- EZH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
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别名
- EZH2
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背景
- EZH2 Antibody: EZH2 was initially identified as a homolog of the drosophila Enhancer of Zeste through exon trap screening of chromosome 21. Both EZH2 and the related protein EZH1 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair. Overexpression of EZH2 has been reported as a marker for advanced and metastatic cancers.
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基因ID
- 2146
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UniProt
- Q15910
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途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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