PARL 抗体 (N-Term)
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北京 101111
Quick Overview for PARL 抗体 (N-Term) (ABIN6990962)
抗原
See all PARL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 40-90, N-Term
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纯化方法
- PARL Antibody is affinity chromatography purified via peptide column.
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免疫原
- PARL antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PARL. The immunogen is located within amino acids 40 - 90 of PARL.
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亚型
- IgG
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anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibody
PARL 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 兔, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibodyPARL 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 1-170) antibodyPARL 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 97-146) antibodyPARL 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 兔, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 112-167) antibodyPARL 适用: 人 ELISA 宿主: 小鼠 Monoclonal 8C4B2 unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 1-170) antibodyPARL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 2-100) antibodyPARL 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4F4 unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibodyPARL 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibodyPARL 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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PARL antibody can be used for detection of PARL by Western blot at 1 - 2 μ,g/mL. Despite its predicted molecular weight of ~42 kDa, PARL is observed at a higher molecular weight in SDS-PAGE. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PARL Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- PARL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- PARL (Presenilin Associated, Rhomboid-Like (PARL))
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别名
- PARL
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背景
- PARL Antibody: PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARL's association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimer's disease through its associations with presenilin-1 and -2. Multiple isoforms of PARL are known to exist.
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基因ID
- 55486
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UniProt
- Q9H300
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途径
- Autophagy
抗原
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