Endonuclease G 抗体 (N-Term)
Quick Overview for Endonuclease G 抗体 (N-Term) (ABIN6990798)
抗原
See all Endonuclease G (ENDOG) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 40-90, N-Term
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纯化方法
- EndoG Antibody is affinity chromatography purified via peptide column.
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免疫原
- Anti-EndoG antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human ENDOG. The immunogen is located within amino acids 40-90 of EndoG.
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亚型
- IgG
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anti-Endonuclease G (ENDOG) (AA 101-200) antibody
ENDOG 适用: 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 16-290) antibodyENDOG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 55-70) antibodyENDOG 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 49-297) antibodyENDOG 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 50-297) antibodyENDOG 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (C-Term) antibodyENDOG 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 斑马鱼, Bat, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 76-170) antibodyENDOG 适用: 人, 大鼠, 小鼠 WB 宿主: 小鼠 Monoclonal 7G1C10 unconjugated
anti-Endonuclease G (ENDOG) (AA 1-294) antibodyENDOG 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endonuclease G (ENDOG) (AA 188-217), (C-Term) antibodyENDOG 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB19287 unconjugated
anti-Endonuclease G (ENDOG) (Middle Region) antibodyENDOG 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 斑马鱼, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 0.5-2 μ,g/mL, IF: 20 μ,g/mL, IHC: 2.5-15 μ,g/mL.
Antibody validated: Western Blot in human and mouse samples, Immunofluorescence and Immunohistochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- EndoG Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- EndoG antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Endonuclease G (ENDOG)
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别名
- EndoG
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背景
- EndoG Antibody: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (endoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans. EndooG also cleaves DNA in vitro.
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分子量
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Predicted: 33kD
Observed: 33kD kDa -
基因ID
- 2021
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NCBI登录号
- NP_004426
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UniProt
- Q14249
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途径
- Apoptosis
抗原
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