Nicastrin 抗体 (AA 370-420)
Quick Overview for Nicastrin 抗体 (AA 370-420) (ABIN6990692)
抗原
See all Nicastrin (NCSTN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 370-420
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纯化方法
- Nicastrin Antibody is affinity chromatography purified via peptide column.
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免疫原
- Nicastrin antibody was raised against a 18 amino acid synthetic peptide from near the center of human Nicastrin. The immunogen is located within amino acids 370 - 420 of Nicastrin.
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亚型
- IgG
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anti-Nicastrin (NCSTN) (AA 16-115) antibody
NCSTN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 429-669) antibodyNCSTN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 21-120) antibodyNCSTN 适用: 小鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 99-133) antibodyNCSTN 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB53031 unconjugated
anti-Nicastrin (NCSTN) (AA 1-689) antibodyNCSTN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 16-115) antibodyNCSTN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E8 unconjugated
anti-Nicastrin (NCSTN) (C-Term) antibodyNCSTN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 420-655) antibodyNCSTN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 35-534) antibodyNCSTN 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (Center) antibodyNCSTN 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Nicastrin antibody can be used for detection of Nicastrin by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Nicastrin Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- Nicastrin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Nicastrin (NCSTN)
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别名
- Nicastrin
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背景
- Nicastrin Antibody: Nicastrin, in addition to presenilin, PEN2, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of Nicastrin expression results in mouse embryonic lethality.
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基因ID
- 23385
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NCBI登录号
- NP_056146
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UniProt
- Q92542
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途径
- Notch Signaling, Neurotrophin Signaling Pathway
抗原
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