DDX58 抗体
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北京 101111
Quick Overview for DDX58 抗体 (ABIN6990681)
抗原
See all DDX58 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- RIG-1 Antibody is DEAE purified.
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免疫原
- RIG-1 antibody was raised against human GST-tagged RIG-1 protein.
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亚型
- IgG
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应用备注
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RIG-1 antibody can be used for the detection of RIG-1 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human and rat samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- RIG-1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- RIG-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
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别名
- RIG-1
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背景
- RIG-1 Antibody: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKε, through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
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基因ID
- 23586
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UniProt
- O95786
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途径
- Activation of Innate immune Response, Hepatitis C
抗原
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