Claudin 1 抗体 (C-Term)
Quick Overview for Claudin 1 抗体 (C-Term) (ABIN6990551)
抗原
See all Claudin 1 (CLDN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- CLDN1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- Anti-CLDN1 antibody was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of human CLDN1. The immunogen is located within the last 50 amino acids of CLDN1.
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亚型
- IgG
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anti-Claudin 1 (CLDN1) (AA 1-211) antibody
CLDN1 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 1C5-D9 unconjugated
anti-Claudin 1 (CLDN1) (AA 1-211) antibodyCLDN1 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 2E2-H5 unconjugated
anti-Claudin 1 (CLDN1) (AA 121-211) antibodyCLDN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 50-197) antibodyCLDN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 1-212) antibodyCLDN1 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1C5-D9 unconjugated
anti-Claudin 1 (CLDN1) (C-Term) antibodyCLDN1 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 1-211) antibodyCLDN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 185-224) antibodyCLDN1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (Tyr210) antibodyCLDN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Claudin 1 (CLDN1) (AA 24-161) antibodyCLDN1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1-2 μ,g/mL, ICC: 5 μ,g/mL, IF: 20 μ,g/mL.
Antibody validated: Western Blot in human and rat samples, Immunocytochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- CLDN1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- CLDN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Claudin 1 (CLDN1)
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别名
- CLDN1
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背景
- CLDN1 Antibody: Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer. Characterization of Claudins expression in human tumors can be an additional diagnostic tool. Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3. Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.
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分子量
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Predicted: 23kD
Observed: 23 kD kDa -
基因ID
- 9076
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UniProt
- O95832
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途径
- Cell-Cell Junction Organization, Hepatitis C
抗原
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