BIRC2 抗体 (C-Term)
Quick Overview for BIRC2 抗体 (C-Term) (ABIN6990458)
抗原
See all BIRC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 540-590, C-Term
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纯化方法
- cIAP Antibody is affinity chromatography purified via peptide column.
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免疫原
- Anti-cIAP antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human cIAP. c-IAP antibody detects both c-IAP1 and c-IAP2. The immunogen is located within amino acids 540-590 of cIAP.
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亚型
- IgG
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anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (AA 1-300) antibody
BIRC2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (C-Term) antibodyBIRC2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (AA 1-618) antibodyBIRC2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) antibodyBIRC2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (AA 344-593) antibodyBIRC2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (AA 148-298) antibodyBIRC2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (C-Term) antibodyBIRC2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1-4 μ,g/mL, IHC: 10 μ,g/mL, IF: 20 μ,g/mL.
Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- cIAP Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- cIAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))
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别名
- cIAP
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背景
- CIAP Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α, by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.
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分子量
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Predicted: 70kD
Observed: 70kD kDa -
基因ID
- 329
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NCBI登录号
- NP_001157
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UniProt
- Q13490
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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