Caspase 12 抗体 (AA 170-220)
Quick Overview for Caspase 12 抗体 (AA 170-220) (ABIN6990234)
抗原
See all Caspase 12 (CASP12) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 170-220
-
特异性
- Caspase-12 (large) antibody is predicted to have no cross reactivity to other members in the caspase family.
-
纯化方法
- Caspase-12 (Large) Antibody is affinity chromatography purified via peptide column.
-
免疫原
- Caspase-12 antibody was raised against a synthetic peptide corresponding to 16 amino acids within the large cleavage product of murine caspase-12. The immunogen is located within amino acids 170 - 220 of Caspase-12.
-
亚型
- IgG
-
-
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 201-300) antibody
CASP12 适用: 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 1-413) antibodyCASP12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 1-244) antibodyCASP12 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 165-193) antibodyCASP12 适用: 人 WB, ELISA, IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 71-84) antibodyCASP12 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 61-282) antibodyCASP12 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 100-116) antibodyCASP12 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 1-100) antibodyCASP12 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 165-193) antibodyCASP12 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB31705 unconjugated
anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 95-318), (N-Term) antibodyCASP12 适用: 人, 小鼠, 大鼠 WB, IF, IP, IHC (p) 宿主: 大鼠 Monoclonal 14F7 unconjugated
-
-
应用备注
-
Caspase-12 (large) antibody can be used for the detection of both the propeptide and cleaved forms of caspase-12 by Western blot at 0.25 to 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.
Antibody validated: Western Blot in human, mouse, and rat samples, Immunohistochemistry in human, mouse, and rat samples and Immunofluorescence in human, mouse, and rat samples. All other applications and species not yet tested. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Caspase-12 Antibody is supplied in PBS containing 0.02 % sodium azide. (Large)
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Caspase-12 (Large) antibody can be stored at -20°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
-
- Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
-
别名
- Caspase-12
-
背景
- Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
-
分子量
-
Predicted: 46 kDa
Observed: 46 kDa -
基因ID
- 12364
-
UniProt
- O08736
-
途径
- Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
抗原
-
