EPAS1 抗体 (AA 1-130) (PE)
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- 抗原 See all EPAS1 抗体
- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
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抗原表位
- AA 1-130
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适用
- 人, 大鼠, 小鼠, 猴, 绵羊
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EPAS1 antibody is conjugated to PE
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS)
- 交叉反应
- 人, 猴, 小鼠, 大鼠, 绵羊
- 预测反应
- Cow,Pig,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from mouse HIF2 Alpha
- 亚型
- IgG
- Top Product
- Discover our top product EPAS1 Primary Antibody
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- 应用备注
- FCM 1:20-100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
- 别名
- HIF2 alpha (EPAS1 产品)
- 背景
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Synonyms: HLF, HRF, MOP2, HIF2A, bHLHe73, HIF-2alpha, Endothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, mHLF, HIF-related factor, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha, Epas1
Background: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP3. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
- 基因ID
- 13819
- UniProt
- P97481
- 途径
- Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect
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