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CDK2 抗体 (AA 201-298) (AbBy Fluor® 555)

Name: CDK2 抗体 (AA 201-298) (AbBy Fluor® 555)
SKU: ABIN6978150
Availability: OutOfStock

This anti-CDK2 antibody is a 兔多克隆 antibody detecting CDK2 in WB, FACS, IF (p) 和 IF (cc). Suitable for 人和小鼠.

产品编号 ABIN6978150

发货至: 中国

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Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for CDK2 抗体 (AA 201-298) (AbBy Fluor® 555) (ABIN6978150)

抗原

See all CDK2 抗体

CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This CDK2 antibody is conjugated to AbBy Fluor® 555

应用范围

Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

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AA 201-298

交叉反应

人, 小鼠

预测反应

Rat,Cow,Pig,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human CDK2

亚型

IgG
anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
CDK2 适用: 人, 小鼠 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1A6 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 197-295) antibody
CDK2 适用: 人, 小鼠 WB, IHC, ELISA, IF, FACS 宿主: 小鼠 Monoclonal 1A6 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 211-298) antibody
CDK2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2E8 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
CDK2 适用: 人, 猴 WB, IF, FACS 宿主: 小鼠 Monoclonal 4B4 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) antibody
CDK2 适用: 人 WB, IHC, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
KD Validated CDK2 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB2295 unconjugated Recombinant Antibody

anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
KD Validated CDK2 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 24GB4315 unconjugated Recombinant Antibody

anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
CDK2 适用: 人, 猴 WB, IF, FACS 宿主: 小鼠 Monoclonal 1C4 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 81-298) antibody
CDK2 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 94-198) antibody
CDK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

有效期

12 months
抗原

CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

别名

CDK2

背景

Synonyms: CDKN2, p33(CDK2), Cyclin-dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDK2
Background: Serine/threonine-protein kinase involved in the control of the cell cycle, essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression, controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2, activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis, regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication.

基因ID

1017

UniProt

P24941

途径

PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA