SETD8 抗体 (N-Term)
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北京 101111
Quick Overview for SETD8 抗体 (N-Term) (ABIN6972699)
抗原
See all SETD8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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产品特性
- SET8 (SET-domain containing protein 8, PR-SET7, SETD8, KMT5A) is a SET domain-containing histone methyltransferase that specifically monomethylates histone H4 Lys20. H4 Lys20 monomethylation is enriched during mitosis and is associated with transcriptional repression. SET8 mainly functions in euchromatic regions, playing a role in gene silencing. SET8 knockout is homozyhgous lethal in mice and its function is required for cell cycle progression and cell proliferation. SET8 is required for proper chromosome condensation during interphase and chromosome segregation during mitosis. SET8 is also involved in DNA damage repair, as cells lacking SET8 function accumulate massive amounts of DNA damage. SET8 has been found to methylate p53 at Lys382, indicating a potential mechanism for SET8s role in the DNA damage repair pathway. SET8 / PR-SET7 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
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纯化方法
- Affinity Purified
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免疫原
- This SET8 / PR-SET7 antibody was raised against a peptide corresponding to amino acids within the N-terminal half of human SETD8.
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亚型
- IgG
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anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) (AA 109-272) antibody
SETD8 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 7H1G10 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) (AA 109-272) antibodySETD8 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 5E10F7 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) (N-Term) antibodySETD8 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 小鼠 Monoclonal 43AT551-86 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) (N-Term) antibodySETD8 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 43AT551-86 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) (AA 73-352) antibodySETD8 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) (AA 220-249) antibodySETD8 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB18964 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) (AA 136-258) antibodySETD8 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) antibodySETD8 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) antibodySETD8 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) antibodySETD8 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
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别名
- SET8 / PR-SET7
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分子量
- 45 kDa
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NCBI登录号
- NP_065115
抗原
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