HDAC2 抗体 (AA 473-488)
Quick Overview for HDAC2 抗体 (AA 473-488) (ABIN7540288)
抗原
See all HDAC2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 473-488
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产品特性
- HDAC2 (Histone Deacetylase 2, also designated mammalian RPD3) is a member of the class I mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-e-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the e-amino group of a lysine residue. In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9 and HDAC10), class III (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT-7) and class IV (HDAC11). HDAC2 is associated with many different proteins as YY1 (a mammalian zinc-finger transcription factor). HDAC2 also forms transcriptional repressor complexes containing, among others, HDAC1 or RBBP4. HDAC1, HDAC2 and HDAC3 are also ubiquitously expressed and can deacetylate both Histone H3 and Histone H4 in free histones or nucleosome substrate. HDAC2 antibody (mAb) (Clone 3F3) was raised in a Mouse host. It has been validated for use in Chromatin Immunoprecipitation, Immunocytochemistry, Immunofluorescence and Western blot, it has been shown to react with Human, Mouse and Rat samples.
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纯化方法
- Culture Supernatant
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免疫原
- This HDAC2 antibody was raised against a KLH-conjugated peptide corresponding to amino acids 473-488 of human HDAC2.
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亚型
- IgG1
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anti-Histone Deacetylase 2 (HDAC2) (AA 456-488), (C-Term) antibody
HDAC2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB5718 unconjugated
anti-Histone Deacetylase 2 (HDAC2) antibodyHDAC2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Histone Deacetylase 2 (HDAC2) antibodyHDAC2 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 3B7 unconjugated
anti-Histone Deacetylase 2 (HDAC2) (AA 410-439) antibodyHDAC2 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 2 (HDAC2) antibodyHDAC2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 9H4 unconjugated Recombinant Antibody
anti-Histone Deacetylase 2 (HDAC2) (pSer394) antibodyHDAC2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 2 (HDAC2) (Internal Region) antibodyVerified HDAC2 适用: 人, 小鼠 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Histone Deacetylase 2 (HDAC2) (pSer394) antibodyHDAC2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone Deacetylase 2 (HDAC2) (AA 410-439) antibodyHDAC2 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB24526 unconjugated
anti-Histone Deacetylase 2 (HDAC2) (pSer394) antibodyHDAC2 适用: 人, 小鼠 ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Concentrated culture supernatant containing 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- HDAC2 (Histone Deacetylase 2 (HDAC2))
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别名
- HDAC2
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分子量
- 55 kDa
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NCBI登录号
- NP_001518
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途径
- Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
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