DDB1 抗体 (C-Term)
Quick Overview for DDB1 抗体 (C-Term) (ABIN6971574)
抗原
See all DDB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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产品特性
- DDB1 (DNA damage-binding protein 1, HBV X-associated protein 1, XAP-1, Xeroderma pigmentosum group E-complementing protein) is a DNA binding protein that associates with DNA following UV damage and functions in excision repair. In addition to its function in DNA repair, DDB1 plays a role in normal mitotic exit by regulating Anaphase Promoting Complex (APC) activity. Depletion of DDB1 in mitotic cells significantly delays mitotic exit. DDB1 facilitates the binding of substrates to the Cul4-Roc1 complex and the ubiquitination of selected proteins, including histones H2A, H3 and H4 localized to the sites of DNA damage. It is also involved in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of P53 in response to radiation-induced DNA damage and during DNA replication. In mouse studies, it was identified that loss of DDB1 function prevents hepatocytes from replicating DNA, inducing compensatory proliferation of normal hepatocytes that leads to development of hepatocellular carcinoma. DDB1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
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纯化方法
- Affinity Purified
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免疫原
- This DDB1 antibody was raised against a peptide from the C-terminus of human DDB1.
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亚型
- IgG
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anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibody
Verified DDB1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibodyKO Validated DDB1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyDDB1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibodyDDB1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyDDB1 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (AA 1011-1140) antibodyDDB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (AA 1011-1140) antibodyDDB1 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (AA 1044-1140) antibodyDDB1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C5 unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) antibodyDDB1 适用: 人 WB, IHC, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Damage Specific DNA Binding Protein 1 (DDB1) (C-Term) antibodyDDB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))
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别名
- DDB1
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分子量
- 140 kDa
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NCBI登录号
- NP_001914
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途径
- DNA Damage Repair
抗原
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