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CSF1R 抗体 (PE)

This anti-CSF1R antibody is a 大鼠 单克隆 antibody detecting CSF1R in FACS. Suitable for 小鼠.
产品编号 ABIN7278328
发货至: 中国

Quick Overview for CSF1R 抗体 (PE) (ABIN7278328)

抗原

See all CSF1R 抗体
CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

适用

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小鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This CSF1R antibody is conjugated to PE

应用范围

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Flow Cytometry (FACS)

克隆位点

AFS98
  • 纯化方法

    This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. It is recommended to store the product undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

    亚型

    IgG2a kappa
  • 应用备注

    This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indi- cated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.

    说明

    0.2 mg/mL

    限制

    仅限研究用
  • 缓冲液

    10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, 0.1 % gelatin, pH 7.2

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    2-8°C protected from light

    有效期

    12 months
  • 抗原

    CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

    别名

    CD115 (c-fms)

    背景

    The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid pre- cursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteo- clasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor.

    基因ID

    12978

    UniProt

    P09581

    途径

    RTK signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
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