CTLA4 抗体
Quick Overview for CTLA4 抗体 (ABIN6961459)
抗原
See all CTLA4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- Baboon, Cynomolgus, 猕猴
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纯化方法
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
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内毒素水平
- Low endotoxin: < 0.01 EU/ug
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亚型
- IgG2a kappa
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anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-135) antibody
CTLA4 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) antibody (PE)CTLA4 适用: 人 FACS 宿主: 小鼠 Monoclonal BNI3 PE
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-162) antibodyCTLA4 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 9D2E9 unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) antibodyCTLA4 适用: 人 FACS, IP, ICC, IHC (fro) 宿主: 小鼠 Monoclonal BNI3 unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) antibodyCTLA4 适用: 人 FACS, IP, ICC, IHC (fro) 宿主: 小鼠 Monoclonal BNI3 unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) antibodyCTLA4 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM50 unconjugated Recombinant Antibody
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) antibodyCTLA4 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8B3F8 unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 75-170) antibodyCTLA4 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 41-90) antibodyCTLA4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 52-211) antibodyCTLA4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- This antibody preparation has been quality-tested for flow cytometry using an appropriate cell type. The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system. Tonbo Biosciences tests all of our antibodies by flow cytometry. Citations may be provided as a resource for additional applications that have not been validated by Tonbo Biosciences.
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说明
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2.0 mg/mL
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限制
- 仅限研究用
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缓冲液
- 10 mM NaH2PO4, 150 mM NaCl, pH 7.2
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储存液
- Azide free
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储存条件
- 4 °C
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储存方法
- 2-8°C
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有效期
- 12 months
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- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
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别名
- CD152 (CTLA-4)
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背景
- The BNI3 antibody is specific for human CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The BNI3 antibody may be used for flow cytometric analysis of intracellular or surface CTLA-4 expression, and is also widely used for neutralization of CTLA-4 when expressed at the cell surface. The BNI3 antibody is reported to be cross-reactive with Baboon, Cynomolgus and Rhesus CTLA-4.
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基因ID
- 1493
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途径
- Cancer Immune Checkpoints
抗原
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