EZH2 抗体 (AA 1-343)
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Quick Overview for EZH2 抗体 (AA 1-343) (ABIN6952425)
抗原
See all EZH2 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 1-343
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特异性
- Polyclonal antibody raised in rabbit against the N-terminus (aa1-343) of the mouse EZH2 protein (Enhancer of zeste homolog 2).
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交叉反应
- 小鼠
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纯化方法
- Protein G purified
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免疫原
- recombinant protein
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应用备注
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ChIP/ChIP-seq 2 μg:ChIP
WB 1:1,000
IF 1:1,000 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- PBS, 0.05 % azide, 0.05 % ProClin300
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
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别名
- EZH2
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背景
- EZH2 (UniProt/Swiss-Prot entry Q15910) is a histone-lysine methyltransferase which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression. It is a member of the polycomb group (PcG) family which form multimeric protein complexes and are involved in maintaining the transcriptional repressive state of genes over successive cell generations. The EZH2 activity is dependent on the association with other components of the PRC2 complex (EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7). EZH2 may play a role in the hematopoietic and central nervous systems. Over-expression of EZH2 is observed during advanced stages of prostate cancer and breast cancer.
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UniProt
- Q15910
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途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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