PABPN1 抗体
Quick Overview for PABPN1 抗体 (ABIN6944405)
抗原
See all PABPN1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠
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纯化方法
- Purified by Protein A.
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免疫原
- N terminus human PABPN1
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亚型
- IgG
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anti-Poly A Binding Protein Nuclear 1 (PABPN1) antibody
PABPN1 适用: 人, 小鼠, 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) antibodyPABPN1 适用: 人 WB, ELISA, IF, IHC, FACS 宿主: 兔 Monoclonal 6C3 unconjugated Recombinant Antibody
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (N-Term) antibodyPABPN1 适用: 人, 小鼠, 犬, 大鼠, Cow, 豚鼠, 兔 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) antibodyPABPN1 适用: 人 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (N-Term) antibodyPABPN1 适用: 人, 犬, 大鼠, Cow, 豚鼠, 兔, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (AA 1-100) antibodyPABPN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly A Binding Protein Nuclear 1 (PABPN1) (C-Term) antibodyPABPN1 适用: 人, 小鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))
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别名
- PABPN1
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背景
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Synonyms: Polyadenylate-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, Polyadenylate-binding nuclear protein 1, PABP-2, Poly(A)-binding protein 2, PABII, PABPN1
Background: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484).
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基因ID
- 8106
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UniProt
- Q86U42
抗原
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