Notch1 抗体
Quick Overview for Notch1 抗体 (ABIN6944302)
抗原
See all Notch1 (NOTCH1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant human Notch1 between 2500 to 2600 amino acids
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亚型
- IgG
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anti-Notch 1 (NOTCH1) antibody (APC)
NOTCH1 适用: 人, 小鼠 ICFC 宿主: 小鼠 Monoclonal mN1A APC
anti-Notch 1 (NOTCH1) antibody (PE)NOTCH1 适用: 人, 小鼠 ICFC 宿主: 小鼠 Monoclonal mN1A PE
anti-Notch 1 (NOTCH1) (AA 1919-2079) antibodyNOTCH1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Notch 1 (NOTCH1) (AA 2101-2300) antibodyNOTCH1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Notch 1 (NOTCH1) (Cleaved-Val1754) antibodyNOTCH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Notch 1 (NOTCH1) (AA 20-216) antibodyNOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 unconjugated
anti-Notch 1 (NOTCH1) (AA 20-216) antibody (HRP)NOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 HRP
anti-Notch 1 (NOTCH1) (AA 20-216) antibody (FITC)NOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 FITC
anti-Notch 1 (NOTCH1) (AA 20-216) antibody (Biotin)NOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 Biotin
anti-Notch 1 (NOTCH1) (AA 20-216) antibody (PE)NOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 PE
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应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
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别名
- Notch 1
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背景
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Synonyms: Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1, Notch 1, hN1
Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
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基因ID
- 4851
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UniProt
- P46531
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途径
- Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
抗原
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