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MUC1 抗体

This anti-MUC1 antibody is a 兔 单克隆 antibody detecting MUC1 in IHC, WB, FACS, IHC (p) 和 IF (cc). Suitable for 人 和 小鼠.
产品编号 ABIN6944166
发货至: 中国

Quick Overview for MUC1 抗体 (ABIN6944166)

抗原

See all MUC1 抗体
MUC1 (Mucin 1 (MUC1))

适用

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克隆类型

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单克隆

标记

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This MUC1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

克隆位点

5G5
  • 交叉反应

    人, 小鼠

    纯化方法

    Purified by Protein A.

    免疫原

    Human MUC1 between 1-100 amino acids

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    IHC()

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    MUC1 (Mucin 1 (MUC1))

    别名

    MUC1

    背景

    Synonyms: Mucin-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, PEMT, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin, CD_antigen: CD227, MUC-1, CA 15-3, KL-6, PUM, PEM, EMA, MUC1

    Background: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

    基因ID

    4582

    UniProt

    P15941

    途径

    Negative Regulation of intrinsic apoptotic Signaling
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