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HDAC2 抗体

This anti-HDAC2 antibody is a 小鼠 单克隆 antibody detecting HDAC2 in WB, ELISA, IF (cc), ChIP-seq 和 DB. Suitable for 人.
产品编号 ABIN6943609
发货至: 中国

Quick Overview for HDAC2 抗体 (ABIN6943609)

抗原

See all HDAC2 抗体
HDAC2 (Histone Deacetylase 2 (HDAC2))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This HDAC2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), ChIP DNA-Sequencing (ChIP-seq), Dot Blot (DB)

克隆位点

7G5
  • 交叉反应

    纯化方法

    Protein A purified monoclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300

    免疫原

    Monoclonal antibody raised in mouse against human HDAC2 (Histone deacetylase 2), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal region of the protein

    亚型

    IgG1
  • 应用备注

    WB 1:300-5000
    ELISA 1:500-1000
    IF(ICC) 1:50-200
    dot-blot()
    ChIP-seq()

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    2 μg/μL

    缓冲液

    PBS with 0.05 % sodium azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    HDAC2 (Histone Deacetylase 2 (HDAC2))

    别名

    HDAC2

    背景

    Synonyms: HD2, RPD3, YAF1

    Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

    基因ID

    3066

    UniProt

    Q92769

    途径

    Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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