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H2AFX 抗体

This anti-H2AFX antibody is a 兔 单克隆 antibody detecting H2AFX in WB, IHC (p), IF (p) 和 IF (cc). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6943600
发货至: 中国

Quick Overview for H2AFX 抗体 (ABIN6943600)

抗原

See all H2AFX 抗体
H2AFX (H2A Histone Family, Member X (H2AFX))

适用

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人, 小鼠, 大鼠

宿主

  • 155
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克隆类型

  • 127
  • 48
单克隆

标记

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This H2AFX antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

克隆位点

9C9
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    Synthetic peptide within human Histone H2A.X aa 1-50

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    H2AFX (H2A Histone Family, Member X (H2AFX))

    别名

    H2AFX

    背景

    Synonyms: Histone H2A.X, Histone H2AX, H2a/x, H2AX, H2AFX., H2A histone family member X.

    Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

    基因ID

    3014

    UniProt

    P16104

    途径

    Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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