Cytokeratin 8/18 抗体
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北京 101111
Quick Overview for Cytokeratin 8/18 抗体 (ABIN6942805)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Full length protein
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亚型
- IgG
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anti-Cytokeratin 8/18 antibody
适用: 人 WB, IF, FACS, IHC, StM 宿主: 小鼠 Monoclonal B22-1-B23-1 unconjugated
anti-Cytokeratin 8/18 antibody适用: 人 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal KRT8-803-KRT18-835 unconjugated
anti-Cytokeratin 8/18 antibody适用: 人 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal KRT8-803-KRT18-835 unconjugated
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应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- Cytokeratin 8/18
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别名
- Cytokeratin 8+18
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背景
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Synonyms: KeRatin, type II cytoskeletal 8, CytokeRatin-8, KeRatin-8, Type-II keRatin Kb8, KeRatin, type I cytoskeletal 18, Cell prolifeRation-inducing gene 46 protein, CytokeRatin-18, KeRatin-18, CK-8, K8, KRT8, CYK8, CK-18, K18, KRT18, CYK18
Background: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. They have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors. The Cytokeratin 8 and 18 pair are normally expressed in simple epithelia, but not in stratified epithelial cells. Research indicates that squamous cell carcinomas derived from stratified epithelia show abnormal expression of Cytokeratin 8 and 18, although it is not known whether these proteins contribute to the malignant phenotype of the cells. Expression of Cytokeratin 8 and 18 in oral squamous cell carcinomas is an independent prognostic marker that indicates a poor prognosis. Cytokeratin 8 expression correlates with malignancy in leukoplakia and carcinomas of the head and neck, it is expressed in all non-small-cell lung cancers. Cytokeratin 8 has been shown to possess extracellular epitopes on tumor cells, which may represent valuable targets for therapy.
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UniProt
- P05783, P05787
抗原
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