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Tyrosinase-Related Protein 1 抗体 (AA 257-377)

This anti-Tyrosinase-Related Protein 1 antibody is a 小鼠 单克隆 antibody detecting Tyrosinase-Related Protein 1 in IHC, ELISA, StM 和 Coat. Suitable for 人.
产品编号 ABIN6940830
发货至: 中国
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Quick Overview for Tyrosinase-Related Protein 1 抗体 (AA 257-377) (ABIN6940830)

抗原

See all Tyrosinase-Related Protein 1 (TYRP1) 抗体
Tyrosinase-Related Protein 1 (TYRP1)

适用

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宿主

  • 113
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  • 1
小鼠

克隆类型

  • 86
  • 68
  • 2
单克隆

标记

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This Tyrosinase-Related Protein 1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), ELISA, Staining Methods (StM), Coating (Coat)

克隆位点

TYRP1-3280
  • 抗原表位

    • 23
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    • 1
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    AA 257-377

    特异性

    It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

    纯化方法

    Purified by Protein A/G

    免疫原

    A recombinant fragment (around aa 257-377) of human TYRP1 protein (exact sequence is proprietary)

    亚型

    IgG2b kappa
  • 应用备注

    Positive Control: SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Human skin or melanoma tissues (IHC).

    Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-80 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    有效期

    24 months
  • 抗原

    Tyrosinase-Related Protein 1 (TYRP1)

    别名

    TYRP1

    分子量

    75kDa

    基因ID

    7306

    UniProt

    P17643
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