PPP3R1 抗体
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北京 101111
Quick Overview for PPP3R1 抗体 (ABIN6940383)
抗原
See all PPP3R1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Calcineurin B / PPP3R1 Antibody
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特异性
- Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
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纯化方法
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human Calcineurin B protein
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亚型
- IgG2a, kappa
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anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-170) antibody
PPP3R1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E1 unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-170) antibodyPPP3R1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 11-170) antibodyPPP3R1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 2-170) antibodyPPP3R1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-154) antibodyPPP3R1 适用: 人, 大鼠, 小鼠, Cow, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 11-170) antibodyPPP3R1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (N-Term) antibodyPPP3R1 适用: 人, 大鼠, 小鼠, Cow, 非洲爪蟾, 豚鼠, 马, 兔, 斑马鱼, 小鸡, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人 IHC 宿主: 小鼠 Monoclonal CALNB-2342 unconjugated
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应用备注
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Positive Control: HeLa, MCF-7 or A431 cells. Human brain, breast or stomach tissue.
Known Application: ELISA (For coating, order antibody without BSA), Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
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别名
- PPP3R1
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背景
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calcineurin B, type I (19 kDa), Calcineurin subunit B type 1, CALNB1, Cna2, CNB, CNB1, Ppp3r1, protein phosphatase 3 (formerly 2B), regulatory subunit B, 19 kDa, alpha isoform (calcineurin B, type I)
breast or stomach tissue., HeLa, MCF-7 or A431 cells. Human brain
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分子量
- 19kDa
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基因ID
- 5534, 280604
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UniProt
- P63098
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途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
抗原
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