POMC 抗体 (AA 25-39)
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北京 101111
Quick Overview for POMC 抗体 (AA 25-39) (ABIN6940341)
抗原
See all POMC 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 25-39
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特异性
- ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to CLIP (aa25-39 of ACTH), does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. '
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纯化方法
- Purified by Protein A/G
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免疫原
- Synthetic peptide corresponding to aa25-39 of human ACTH (NGAEDESAEAFPLEF)
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亚型
- IgG1 kappa
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anti-Proopiomelanocortin (POMC) (C-Term) antibody
Verified POMC 适用: 人 IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Proopiomelanocortin (POMC) (AA 1-267) antibodyPOMC 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Proopiomelanocortin (POMC) (N-Term) antibodyPOMC 适用: 人, 小鼠, 大鼠 IHC, ELISA, FACS, IF, Coat, StM 宿主: 小鼠 Monoclonal 57 unconjugated
anti-Proopiomelanocortin (POMC) (AA 1-150) antibodyPOMC 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 6D2B5 unconjugated
anti-Proopiomelanocortin (POMC) (AA 1-267) antibodyPOMC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Proopiomelanocortin (POMC) antibodyPOMC 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Proopiomelanocortin (POMC) (AA 205-267) antibodyPOMC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E11 unconjugated
anti-Proopiomelanocortin (POMC) (AA 1-267) antibodyPOMC 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Proopiomelanocortin (POMC) (AA 1-150) antibodyPOMC 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5D3A10 unconjugated
anti-Proopiomelanocortin (POMC) (AA 138-176), (Middle Region) antibodyPOMC 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Positive Control: Normal pituitary gland or pituitary tumor.
Known Application: ELISA (For coating, order Ab without BSA), Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- POMC (Proopiomelanocortin (POMC))
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别名
- POMC
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分子量
- ACTH is ~5kDa, and the POMC precursor is ~30kDa. The molecular weight of POMC depends upon isoform variation and post-translational modifications.
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基因ID
- 5443
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UniProt
- P01189
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途径
- Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
抗原
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