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Nkx2-2 抗体 (AA 1-119)

This 小鼠 单克隆 anti-Nkx2-2 antibody (Clone NX2-1523) specifically detects Nkx2-2 in IHC 和 StM. The antibody is reactive with 人 samples.
产品编号 ABIN6940201
发货至: 中国
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Quick Overview for Nkx2-2 抗体 (AA 1-119) (ABIN6940201)

抗原

See all Nkx2-2 抗体
Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

适用

  • 135
  • 54
  • 50
  • 24
  • 6
  • 6
  • 6
  • 5
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2

宿主

  • 85
  • 57
小鼠

克隆类型

  • 92
  • 50
单克隆

标记

  • 57
  • 13
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
This Nkx2-2 antibody is un-conjugated

应用范围

  • 78
  • 60
  • 48
  • 33
  • 28
  • 24
  • 13
  • 13
  • 12
  • 7
  • 7
  • 3
Immunohistochemistry (IHC), Staining Methods (StM)

克隆位点

NX2-1523
  • 抗原表位

    • 33
    • 8
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-119

    特异性

    Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93 % and a specificity of 89 %, and aids in the differential diagnosis of small round cell tumors.

    纯化方法

    Purified by Protein A/G

    免疫原

    Recombinant fragment (around aa1-119) of human NKX2.2 protein (exact sequence is proprietary)

    亚型

    IgG1 kappa
  • 应用备注

    Positive Control: Pancreas or Ewing's Sarcoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-80 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    有效期

    24 months
  • 抗原

    Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

    别名

    NKX2-2

    分子量

    40-50kDa

    基因ID

    4821

    UniProt

    O95096

    途径

    Dopaminergic Neurogenesis
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