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Recombinant NGFR 抗体 (AA 281-421)

This anti-NGFR antibody is a 小鼠 单克隆 antibody detecting NGFR in IHC, Diff 和 StM. Suitable for 人.
产品编号 ABIN6940191
发货至: 中国

Quick Overview for Recombinant NGFR 抗体 (AA 281-421) (ABIN6940191)

抗原

See all NGFR 抗体
NGFR (Nerve Growth Factor Receptor (NGFR))

抗体类型

Recombinant Antibody

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This NGFR antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Differentiation (Diff), Staining Methods (StM)

克隆位点

RNGFR-1965
  • 抗原表位

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    AA 281-421

    特异性

    It recognizes a glycoprotein of 75 kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

    纯化方法

    Purified by Protein A/G

    免疫原

    Recombinant human p75 NGFR protein fragment (around aa 281-421) (exact sequence is proprietary)

    亚型

    IgG1 kappa
  • 应用备注

    Positive Control: Neuronal axons, Schwann cells and perineural cells of peripheral nerves or tumors of nerve sheath differentiation e. G. Schwannoma, Neurofibroma. Soma and axons of sensory neurons and ganglionic satellite cells. Melanomas.

    Known Application: Immunohistochemistry (Formalin-fixed. Not suitable for frozen tissues.) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-80 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    有效期

    24 months
  • 抗原

    NGFR (Nerve Growth Factor Receptor (NGFR))

    别名

    NGFR

    分子量

    75kDa

    基因ID

    4804

    UniProt

    P08138

    途径

    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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