VISTA 抗体
Quick Overview for VISTA 抗体 (ABIN6938762)
抗原
See all VISTA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment). It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human VISTA protein
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亚型
- IgG2b kappa
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anti-V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) antibody
VISTA 适用: 人 ELISA, IHC, Coat, StM 宿主: 小鼠 Monoclonal VISTA-3007 unconjugated
anti-V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) (AA 33-194) antibodyVISTA 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6E4H3 unconjugated
anti-V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) (AA 37-194) antibodyVISTA 适用: 人 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) antibodyVISTA 适用: 小鼠 ELISA, IHC, BR 宿主: 兔 Chimeric MH5A unconjugated Recombinant Antibody
anti-V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) antibodyVISTA 适用: 人 ELISA, IHC, Coat, StM 宿主: 小鼠 Monoclonal VISTA-2865 unconjugated
anti-V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) antibodyVISTA 适用: 小鼠 ELISA, FACS, BP 宿主: 兔 Chimeric 13F3 unconjugated Recombinant Antibody
anti-V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) (AA 1-311) antibodyVISTA 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) (AA 33-194) antibodyVISTA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: Human spleen or placenta tissue (IHC).
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))
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别名
- VSIR
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背景
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B7H5, DD1alpha, GI24, PD-1H, PDCD1 homolog, Platelet receptor Gi24, PP2135,Stress-induced secreted protein 1 (SISP1), V domain Ig suppressor of T cell activation,V Set Immuno-regulatory Receptor,VISTA / GI24 (Negative Regulator of Immune Response)
Cellular localisation: Cell Surface and Cytoplasmic -
分子量
- 34kDa
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基因ID
- 64115, 47382
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UniProt
- Q9H7M9
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途径
- Cancer Immune Checkpoints
抗原
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