ROR2 抗体
Quick Overview for ROR2 抗体 (ABIN6938323)
抗原
See all ROR2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt-1 and Wnt-3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1, or the autosomal recessive skeletal disorder, Robinow syndrome.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Human cultured keratinocytes
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亚型
- IgG
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anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 683-934) antibody
ROR2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 59-155) antibodyROR2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6F2D10 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 19-50), (N-Term) antibodyROR2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB01507-01508 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 19-50) antibodyROR2 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 752-926) antibodyROR2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 915-943), (C-Term) antibodyROR2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01510 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (Internal Region) antibodyROR2 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 34-143) antibodyROR2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E1 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) antibodyROR2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ROR2-1911 unconjugated
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (AA 100-200) antibodyROR2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human breast, pancreas, kidney or GIST.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
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别名
- ROR2
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背景
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BR, CD49 antigen-like family member B, ROR2, Collagen receptor, DX5, Glycoprotein Ia deficiency included (GPIa), Human platelet alloantigen system 5 (HPA5 included), Integrin alpha II (ITGA2), Platelet alloantigen Br(a), included, Platelet glycoprotein Ia/IIa, Platelet membrane glycoprotein Ia, VLA2,ROR2
Cellular localisation: Cell membrane. -
分子量
- 120kDa
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基因ID
- 4920, 644776, 98255
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UniProt
- Q01974
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途径
- RTK signaling, WNT signaling
抗原
-
