PPP3R1 抗体
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- 抗原 See all PPP3R1 抗体
- PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PPP3R1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
- 交叉反应 （详细）
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length Calcineurin B protein
- 克隆位点
- CALNB-2342
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product PPP3R1 Primary Antibody
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anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-170) antibody
PPP3R1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E1 unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-170) antibodyPPP3R1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 11-170) antibodyPPP3R1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-154) antibodyPPP3R1 适用: 人, 大鼠, 小鼠, Cow, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 11-170) antibodyPPP3R1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CALNB-2342 unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (N-Term) antibodyPPP3R1 适用: 人, 大鼠, 小鼠, Cow, 豚鼠, 马, 兔, 非洲爪蟾, 斑马鱼, 小鸡, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
- 别名
- PPP3R1 (PPP3R1 产品)
- 别名
- si:ch211-274c22.8 antibody, canb antibody, CALNB1 antibody, CNB antibody, CNB1 antibody, CaNB1 antibody, Cnb1 antibody, MCIP1 antibody, protein phosphatase 3, regulatory subunit B, alpha a antibody, protein phosphatase 3 regulatory subunit B, alpha S homeolog antibody, protein phosphatase 3 regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) antibody, ppp3r1a antibody, ppp3r1.S antibody, PPP3R1 antibody, Ppp3r1 antibody
- 背景
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Calcineurin B, type I (19 kDa), Calcineurin subunit B type 1, CALNB1, CNB1, PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform, Protein phosphatase 3 regulatory subunit B alpha, Protein phosphatase 3 regulatory subunit B alpha isoform 1,Calcineurin B / PPP3R1
Cellular localisation: Cytoplasmic and Cell Surface - 分子量
- 19kDa
- 基因ID
- 5534, 280604
- UniProt
- P63098
- 途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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