PPP3R1 抗体
Quick Overview for PPP3R1 抗体 (ABIN6938230)
抗原
See all PPP3R1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length Calcineurin B protein
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亚型
- IgG1 kappa
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anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-170) antibody
PPP3R1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E1 unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-170) antibodyPPP3R1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 11-170) antibodyPPP3R1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 2-170) antibodyPPP3R1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-154) antibodyPPP3R1 适用: 人, 小鼠, 大鼠, Cow, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 11-170) antibodyPPP3R1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CALNB-2342 unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (N-Term) antibodyPPP3R1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 非洲爪蟾, 斑马鱼, 小鸡, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
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别名
- PPP3R1
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背景
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Calcineurin B, type I (19 kDa), Calcineurin subunit B type 1, CALNB1, CNB1, PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform, Protein phosphatase 3 regulatory subunit B alpha, Protein phosphatase 3 regulatory subunit B alpha isoform 1,Calcineurin B / PPP3R1
Cellular localisation: Cytoplasmic and Cell Surface -
分子量
- 19kDa
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基因ID
- 5534, 280604
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UniProt
- P63098
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途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
抗原
-
