PPP3CA 抗体
Quick Overview for PPP3CA 抗体 (ABIN6938228)
抗原
See all PPP3CA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length Calcineurin A protein
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亚型
- IgG1 kappa
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anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (AA 1-84) antibody
PPP3CA 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 2G8 unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (AA 1-511) antibodyPPP3CA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (Middle Region) antibodyPPP3CA 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, 斑马鱼, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (AA 21-51) antibodyPPP3CA 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) antibodyPPP3CA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) antibodyPPP3CA 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CALNA-2353 unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (N-Term) antibodyPPP3CA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (N-Term) antibodyPPP3CA 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) antibodyPPP3CA 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (AA 364-283) antibodyPPP3CA 适用: 人, 小鼠, 大鼠, 犬, 兔 WB, IHC, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
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别名
- PPP3CA
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背景
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Calcineurin A alpha, Calcineurin A1, Calcineurin A, Calmodulin-dependent calcineurin A subunit alpha isoform, CALN, CALNA1, CAM-PRP catalytic subunit, CCN1, CNA alpha, CNA1, Ppp3ca, Protein phosphatase 2B catalytic subunit (PPP2B), Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform (PPP3CA),Calcineurin A / PPP3CA
Cellular localisation: Cytoplasmic and Cell Surface -
分子量
- 62kDa
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基因ID
- 5530, 435512
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UniProt
- Q08209
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途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
抗原
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