ICOSLG 抗体 (AA 23-149)
Quick Overview for ICOSLG 抗体 (AA 23-149) (ABIN6937472)
抗原
See all ICOSLG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 23-149
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特异性
- This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 23-149) (exact sequence is proprietary)
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亚型
- IgG2b kappa
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anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 23-249) antibody
ICOSLG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 23-149) antibodyICOSLG 适用: 人 WB, ELISA, IHC, FACS, IF, Coat, StM 宿主: 小鼠 Monoclonal ICOSL-3111 unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) antibodyICOSLG 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1G6E1 unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 58-249) antibodyICOSLG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 197-246) antibodyICOSLG 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 23-149) antibodyICOSLG 适用: 人 ELISA, IHC, Coat, StM, ISt 宿主: 小鼠 Monoclonal ICOSL-3260 unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) antibodyICOSLG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-120) antibodyICOSLG 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) antibodyICOSLG 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 20-302) antibodyICOSLG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E2 unconjugated
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应用备注
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Known_Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HL60, HuT78 and HUVEC cells. Prostate or Colon Carcinoma.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
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别名
- ICOSLG
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背景
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B7 homolog 2 (B7H2), B7 like protein Gl50, B7 related protein 1 (B7RP1), CD275, CD275 antigen, GL50, ICOS LG, ICOS ligand (ICOSL), Inducible T cell co stimulator ligand, LICOS, Transmembrane protein B7 H2 ICOS ligand,ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target)
Cellular localisation: Cell Surface -
分子量
- 36kDa
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基因ID
- 23308, 14155
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UniProt
- O75144
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途径
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
抗原
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