TIM3 抗体 (AA 22-202)
Quick Overview for TIM3 抗体 (AA 22-202) (ABIN6937366)
抗原
See all TIM3 (TIM 3) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 22-202
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特异性
- TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment of human TIM3 protein (around aa 22-202) (exact sequence is proprietary)
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亚型
- IgG2a kappa
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anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (Internal Region) antibody
Verified TIM 3 适用: 人 FACS, WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-202) antibodyTIM 3 适用: 人 ELISA, IHC, Coat, StM 宿主: 小鼠 Monoclonal TIM3-3113 unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 167-194) antibodyTIM 3 适用: 人 WB 宿主: 兔 Polyclonal RB41963 unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-202) antibodyTIM 3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-202) antibodyTIM 3 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 7C8A7 unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 224-301) antibodyTIM 3 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 2A7A6 unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) antibodyTIM 3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) antibodyTIM 3 适用: 人 IHC 宿主: 兔 Monoclonal MSVA-366R unconjugated Recombinant Antibody
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-202) antibodyTIM 3 适用: 人 FACS, WB 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-202) antibodyTIM 3 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
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应用备注
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Known_Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: PC3, BT474, HepG2, HDLM-2 or Daudi cells. Tonsil, lymph node or spleen.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
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别名
- HAVCR2
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物质类
- Virus
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背景
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CD366, HAVR2, Hepatitis A virus cellular receptor 2 (HAVCR2), Kidney injury molecule 3 (KIM3), T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM3, TIMD3,TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker)
Cellular localisation: Cell Surface -
分子量
- 60kDa
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基因ID
- 84868, 710500
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UniProt
- Q8TDQ0
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途径
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
抗原
-
