Gelsolin 抗体
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北京 101111
Quick Overview for Gelsolin 抗体 (ABIN6937348)
抗原
See all Gelsolin (GSN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human full-length protein
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亚型
- IgG1 kappa
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anti-Gelsolin (GSN) (AA 170-423) antibody
GSN 适用: Cow WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Gelsolin (GSN) (AA 577-771) antibodyGSN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) (AA 674-782) antibodyGSN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) (AA 543-782) antibodyGSN 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) (AA 673-782) antibodyGSN 适用: 人 WB, IP, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3G5 unconjugated
anti-Gelsolin (GSN) antibodyGSN 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5E3B9 unconjugated
anti-Gelsolin (GSN) (AA 432-553) antibodyGSN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Gelsolin (GSN) (AA 432-625) antibodyGSN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) (AA 1-782) antibodyGSN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Gelsolin (GSN) (C-Term) antibodyKO Validated GSN 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: MCF cell lysate, Tonsil.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- Gelsolin (GSN)
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别名
- GSN
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背景
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Actin depolymerizing factor, ADF, AGEL, Brevin, Gsn,Gelsolin / Actin-depolymerizing Factor
Cellular localisation: Cytoplasm and secreted -
分子量
- 90kDa
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基因ID
- 2934, 522373
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UniProt
- P06396
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途径
- Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy
抗原
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