alpha Actinin 4 抗体
Quick Overview for alpha Actinin 4 抗体 (ABIN6936363)
抗原
See all alpha Actinin 4 (ACTN4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human ACTN4 protein
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亚型
- IgG
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anti-Actinin, alpha 4 (ACTN4) (AA 592-701) antibody
ACTN4 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4D10 unconjugated
anti-Actinin, alpha 4 (ACTN4) (AA 1-269) antibodyACTN4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 4 (ACTN4) (C-Term) antibodyACTN4 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 4 (ACTN4) antibodyACTN4 适用: 人 WB, IP, IF 宿主: 兔 Monoclonal unconjugated
anti-Actinin, alpha 4 (ACTN4) (AA 160-440) antibodyACTN4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 4 (ACTN4) (N-Term) antibodyACTN4 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 斑马鱼, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 4 (ACTN4) antibodyACTN4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 4 (ACTN4) (AA 1-911) antibodyACTN4 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 4 (ACTN4) (AA 561-661) antibodyACTN4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 4 (ACTN4) (AA 785-813), (C-Term) antibodyACTN4 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB15705 unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human colon or kidney tissue (IHC).
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))
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别名
- ACTN4
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背景
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F-actin cross-linking protein, Focal segmental glomerulosclerosis 1 (FSG1), Non-muscle alpha-actinin-4,Alpha Actinin 4 / ACTN4
Cellular localisation: Nucleus. Cytoplasm. -
分子量
- 105kDa
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基因ID
- 81, 270291
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UniProt
- O43707
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途径
- Proton Transport
抗原
-
