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alpha Actinin 4 抗体 (N-Term)

ACTN4 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 斑马鱼, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2775288
发货至: 中国
  • 抗原 See all alpha Actinin 4 (ACTN4) 抗体
    alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))
    抗原表位
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 86
    • 43
    • 40
    • 8
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 斑马鱼, 马, 兔
    宿主
    • 79
    • 7
    克隆类型
    • 66
    • 19
    多克隆
    标记
    • 54
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This alpha Actinin 4 antibody is un-conjugated
    应用范围
    • 67
    • 29
    • 26
    • 18
    • 16
    • 15
    • 13
    • 12
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    LIHRHRPELI EYDKLRKDDP VTNLNNAFEV AEKYLDIPKM LDAEDIVNTA
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
    产品特性
    This is a rabbit polyclonal antibody against ACTN4. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human ACTN4
    Top Product
    Discover our top product ACTN4 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 911 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Wei, Gao, Du, Su, Xu: "Angiogenin enhances cell migration by regulating stress fiber assembly and focal adhesion dynamics." in: PLoS ONE, Vol. 6, Issue 12, pp. e28797, (2011) (PubMed).

    Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

  • 抗原
    alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))
    别名
    ACTN4 (ACTN4 产品)
    别名
    fsgs antibody, fsgs1 antibody, C77391 antibody, ACTININ-4 antibody, FSGS antibody, FSGS1 antibody, wu:fb53f05 antibody, zgc:63508 antibody, actinin alpha 4 antibody, actinin, alpha 4 antibody, actinin alpha 4 S homeolog antibody, actn4 antibody, ACTN4 antibody, Actn4 antibody, actn4.S antibody
    背景
    Alpha actinins belong to the spectrin superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN4 is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in its gene have been associated with focal and segmental glomerulosclerosis.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
    Alias Symbols: DKFZp686K23158, FSGS, FSGS1, ACTININ-4
    Protein Interaction Partner: MYOZ2, HUWE1, UBC, BMP7, ACTN3, SUMO2, SUMO3, GNB2, SUMO1, NEDD8, MDM2, HGS, SF3A3, VCP, CDKN2A, ACTN1, PDLIM1, UBD, IGSF8, ICAM1, CD81, SVIL, Fcho2, POT1, VCAM1, TXN, RPS27, MAPK7, KPNA2, ITGA4, FN1, ESR1, CDH1, TRAF3IP1, FMNL1, NOS3, ACTN2, UBASH3B, SHC
    Protein Size: 911
    分子量
    100 kDa
    基因ID
    81
    NCBI登录号
    NM_004924, NP_004915
    UniProt
    O43707
    途径
    Proton Transport
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