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PRKDC 抗体 (AA 150-200) (FITC)

This anti-PRKDC antibody is a 兔多克隆 antibody detecting PRKDC in WB. Suitable for 人, 小鼠和大鼠.

产品编号 ABIN685424

发货至: 中国

Quick Overview for PRKDC 抗体 (AA 150-200) (FITC) (ABIN685424)

抗原

See all PRKDC 抗体

PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

适用

164
88
48
5
2
2
2
2
1
1

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

96
10
10
7
5
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3

This PRKDC antibody is conjugated to FITC

应用范围

78
75
63
33
30
28
28
27
20
14
7
6
5
4
2
2
2
1

Western Blotting (WB)

Discover our top product PRKDC Primary Antibody

抗原表位
26

13

11

8

8

7

6

4

4

4

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 150-200

交叉反应

人, 大鼠

预测反应

Mouse,Dog,Cow,Horse,Chicken,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human DNA PKcs

亚型

IgG
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 4019-4128) antibody
PRKDC 适用: 人 ELISA, WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 1B9 unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody
PRKDC 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3H6 unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody
PRKDC 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (C-Term) antibody
PRKDC 适用: 人, 小鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 151-300) antibody
PRKDC 适用: 人, 大鼠 ELISA, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (C-Term) antibody
PRKDC 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 3899-4128) antibody
PRKDC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 4075-4104), (C-Term) antibody
PRKDC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3465-3466 unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 4019-4129) antibody
PRKDC 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2A8 unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 4019-4129) antibody
PRKDC 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1B9 unconjugated

应用备注

IF(IHC-P) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

有效期

12 months
抗原

PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

别名

Dnapk/Prkdc

背景

Synonyms: HYRC, p350, DNAPK, DNPK1, HYRC1, IMD26, XRCC7, DNA-PKcs, DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, p460, PRKDC
Background: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2, negatively regulates CRY1 phosphorylation.

基因ID

5591

UniProt

P78527

途径

DNA Damage Repair, Production of Molecular Mediator of Immune Response

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