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PRKDC 抗体 (AA 151-300)

Name: PRKDC 抗体 (AA 151-300)
SKU: ABIN685417
Availability: OutOfStock

PRKDC 适用: 人, 大鼠 ELISA, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded human ovarian tissue labeled with Anti-DNAPK PRKDC Polyclonal Antibody, unconjugated (ABIN685417) followed by incubation with conjugated secondary antibody and DAB staining (PRKDC 抗体 (AA 151-300))

IHC

2 images

产品编号 ABIN685417

发货至: 中国

Datasheet as PDF

抗原 See all PRKDC 抗体

PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
抗原表位
26

13

12

7

7

7

5

4

4

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 151-300
适用
161

91

48

5

2

2

2

2

1
人, 大鼠
宿主
153

21

3

2
兔
Compatible Secondaries
克隆类型
148

31
多克隆
标记
95

11

11

8

5

5

5

5

5

5

5

4

3

3

3

3

3
This PRKDC antibody is un-conjugated
应用范围
84

69

58

36

33

28

27

24

14

13

8

7

5

4

2

2

2

1
ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

交叉反应

人, 大鼠

预测反应

Mouse,Dog,Cow,Horse,Chicken,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human DNA PKcs

亚型

IgG

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anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody
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anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (C-Term) antibody
PRKDC 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 3899-4128) antibody
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anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (pThr2647) antibody
PRKDC 适用: 人 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

别名

DNAPK/PRKDC (PRKDC 产品)

别名

DNA-PKcs antibody, DNAPK antibody, DNPK1 antibody, HYRC antibody, HYRC1 antibody, XRCC7 antibody, p350 antibody, DNA-PKCS antibody, dna-pkcs antibody, dnapk antibody, dnpk1 antibody, hyrc antibody, hyrc1 antibody, prkdc-A antibody, xrcc7 antibody, PRKDC antibody, AI326420 antibody, AU019811 antibody, DNAPDcs antibody, DOXNPH antibody, dxnph antibody, p460 antibody, scid antibody, slip antibody, protein kinase, DNA-activated, catalytic polypeptide antibody, protein kinase, DNA-activated, catalytic polypeptide L homeolog antibody, DNA-dependent protein kinase catalytic subunit antibody, protein kinase, DNA activated, catalytic polypeptide antibody, PRKDC antibody, prkdc.L antibody, LOC100633457 antibody, Prkdc antibody

背景

Synonyms: HYRC, p350, DNAPK, DNPK1, HYRC1, IMD26, XRCC7, DNA-PKcs, DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, p460, PRKDC
Background: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2, negatively regulates CRY1 phosphorylation.

基因ID

5591

UniProt

P78527

途径

DNA Damage Repair, Production of Molecular Mediator of Immune Response