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C3 抗体 (AA 1551-1663)

Name: C3 抗体 (AA 1551-1663)
SKU: ABIN681913
Availability: OutOfStock

This anti-C3 antibody is a 兔多克隆 antibody detecting C3 in WB, ELISA, IHC (fro), IF (p) 和 IHC (p). Suitable for 人, 小鼠和大鼠. This Primary Antibody has been cited in 3+ publications.

Formalin-fixed and paraffin embedded rat liver labeled with Anti-C3 Polyclonal Antibody, Unconjugated (ABIN681913) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, PE conjugated used at 1:200 dilution for 40 minutes at 37°C (C3 抗体 (AA 1551-1663))

ELISA

Formalin-fixed and paraffin embedded mouse kidney labeled with Anti-C3 Polyclonal Antibody, Unconjugated (ABIN681913) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, FITC conjugated used at 1:200 dilution for 40 minutes at 37°C (C3 抗体 (AA 1551-1663))

3 images

(3 references)

产品编号 ABIN681913

发货至: 中国

Datasheet as PDF

Quick Overview for C3 抗体 (AA 1551-1663) (ABIN681913)

抗原

See all C3 抗体

C3 (Complement Component 3 (C3))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This C3 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Discover our top product C3 Primary Antibody

抗原表位
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AA 1551-1663

交叉反应

人, 小鼠, 大鼠

预测反应

Cow,Pig,Horse,Rabbit,Guinea Pig

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Complement C3 alpha chain

亚型

IgG
anti-Complement Component 3 (C3) (AA 1000-1326) antibody
C3 适用: 人 WB, IHC, IP, FACS, ICC 宿主: 兔 Polyclonal unconjugated

anti-Complement Component 3 (C3) (AA 1534-1644) antibody
C3 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5F9 unconjugated

anti-Complement Component 3 (C3) (C-Term) antibody
C3 适用: 人 WB, IP, ICC, IF, IHC (p), ISub 宿主: 兔 Polyclonal unconjugated

anti-Complement Component 3 (C3) (AA 23-300) antibody
C3 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Complement Component 3 (C3) (AA 965-1303) antibody
C3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Complement Component 3 (C3) (AA 1534-1645) antibody
C3 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5F9 unconjugated

anti-Complement Component 3 (C3) antibody
C3 适用: 小鼠 WB, IP, FACS, IF, IA 宿主: 大鼠 Monoclonal 11H9 unconjugated

anti-Complement Component 3 (C3) (AA 966-1313) antibody
C3 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Complement Component 3 (C3) (AA 1353-1382) antibody
C3 适用: 人 WB 宿主: 小鼠 Monoclonal 567CT11-2-3 unconjugated

anti-Complement Component 3 (C3) antibody
C3 适用: 人 ELISA, RID 宿主: 绵羊 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Rogińska, Kawa, Pius-Sadowska, Lejkowska, Łuczkowska, Wiszniewska, Kaarniranta, Paterno, Schmidt, Machaliński, Machalińska: "Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 5306790, (2018) (PubMed).

Zhuang, Han, Li, Kienhöfer, Lee, Shumyak, Meyerholz, Rosadzinski, Rosner, Chan, Xu, Segal, Sobel, Yang, Hoffmann, Reeves: "A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 68, Issue 12, pp. 2917-2928, (2016) (PubMed).

Trang, Hirai, Nabeta, Fuke, Yamaguchi: "Membranoproliferative glomerulonephritis in a calf with nephrotic syndrome." in: Journal of comparative pathology, Vol. 151, Issue 2-3, pp. 162-5, (2014) (PubMed).
抗原

C3 (Complement Component 3 (C3))

别名

Complement C3

背景

Synonyms: ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3
Background: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575).

基因ID

718

UniProt

P01024

途径

Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling