FZD5 抗体 (PE-Cy7)
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北京 101111
Quick Overview for FZD5 抗体 (PE-Cy7) (ABIN681866)
抗原
See all FZD5 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Pig,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Frizzled 5
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亚型
- IgG
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anti-Frizzled Family Receptor 5 (FZD5) (AA 72-161) antibody
FZD5 适用: 人 WB, ELISA, IP, PLA 宿主: 小鼠 Monoclonal 6A3 unconjugated
anti-Frizzled Family Receptor 5 (FZD5) (AA 151-217) antibodyFZD5 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2D12 unconjugated
anti-Frizzled Family Receptor 5 (FZD5) (AA 461-510) antibodyFZD5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 5 (FZD5) (AA 467-516) antibodyFZD5 适用: 人, 小鼠, 大鼠, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 5 (FZD5) (Cytoplasmic Domain) antibodyFZD5 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 5 (FZD5) (N-Term) antibodyFZD5 适用: 人, 小鼠, 大鼠, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 5 (FZD5) (AA 72-161) antibodyFZD5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Frizzled Family Receptor 5 (FZD5) (AA 1-585) antibodyFZD5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 5 (FZD5) (AA 461-510) antibodyFZD5 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 5 (FZD5) (Middle Region) antibodyFZD5 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF (p) (1:100-500)
Not yet tested in other applications. Optimal working dilutions must be determined by the end user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- FZD5 (Frizzled Family Receptor 5 (FZD5))
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别名
- Frizzled 5
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背景
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Synonyms: C2orf31, Frizzled homolog 5, Frizzled-5, Frizzled5, Fz 5, Fz-5, Fz5, FZD 5, hFz5, FZD5, FZD5_HUMAN, FzE 5, FzE5, HFZ 5, Seven transmembrane receptor frizzled 5, Wnt receptor, hFz8, Fz-8, Frizzled-8, FZD8.
Background: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The Frizzled 5 protein is believed to be the receptor for the Wnt5A ligand. Frizzled 5 has been reported to be expressed in fetal kidney, fetal and adult liver, fetal lung, and adult pancreas. ESTs have been isolated from bone, liver/spleen, placenta, and prostate libraries. Frizzled 5 was cloned from a retina cDNA library. Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
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分子量
- 62 kDa
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基因ID
- 7855, 8325
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途径
- WNT signaling
抗原
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