NOTCH3 抗体 (APC)
Quick Overview for NOTCH3 抗体 (APC) (ABIN6722240)
抗原
See all NOTCH3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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亚型
- IgG1 kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS with 0.05 % Proclin300, 1 % BSA
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
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- NOTCH3 (Notch 3 (NOTCH3))
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别名
- Notch3
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背景
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Synonyms: NOTCH3,Notch 3,Notch 3 extracellular truncation,Notch 3 intracellular domain
Background: The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome.
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基因ID
- 4854
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UniProt
- Q9UM47
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途径
- Notch Signaling
抗原
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