CCKBR 抗体 (DyLight 550)
Quick Overview for CCKBR 抗体 (DyLight 550) (ABIN7354667)
抗原
See all CCKBR 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Anti-Human CCKBR DyLight® 550 conjugated Antibody
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序列
- PVYTVVQPVG PRVLQCVHRW PSARVRQTWS
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Human CCKBR DyLight® 550 conjugated Antibody -Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human CCKBR, which shares 80% and 90% amino acid (aa) sequence identity with mouse and rat CCKBR, respectively.
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亚型
- IgG
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anti-Cholecystokinin B Receptor (CCKBR) (Internal Region) antibody
Verified CCKBR 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (AA 301-400) antibodyCCKBR 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (AA 243-333) antibodyCCKBR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (N-Term) antibodyCCKBR 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (C-Term) antibodyCCKBR 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (Extracellular Domain) antibodyCCKBR 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (Cytoplasmic Domain) antibodyCCKBR 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) antibodyCCKBR 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (AA 39-53), (Extracellular) antibodyCCKBR 适用: 小鼠 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (N-Term) antibodyCCKBR 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow Cytometry (Fixed), 1-3 μg/1x106 cells1. Altar CA, Boyar WC (Apr 1989). "Brain CCK-B receptors mediate the suppression of dopamine release by cholecystokinin". Brain Research. 483 (2): 321-6. 2. Noble F, Roques BP (Jul 1999). "CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology". Progress in Neurobiology. 58 (4): 349-79.
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说明
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Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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- CCKBR (Cholecystokinin B Receptor (CCKBR))
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别名
- CCKBR
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背景
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Synonyms: Gastrin/cholecystokinin type B receptor, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R, CCKBR, CCKRB
Tissue Specificity: Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
Background: The cholecystokinin B receptor, also known as CCKBR or CCK2, is a protein that in humans is encoded by the CCKBR gene. This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.
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分子量
- 39 kDa
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基因ID
- 887
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UniProt
- P32239
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途径
- Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour
抗原
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